1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

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Chemical Name:1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol
CAS No.:934243-71-7
Molecular Formula:C₄₁H₅₈O₇Si₂
Molecular Weight:719.078
Hs Code.:

1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

Synonyms:1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

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Chemical Property of 1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

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Technology Process of 1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

There total 8 articles about 1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934243-67-1
2-iodo-3,5-bis(phenylmethoxy)-(2',2'-dimethylpropanoyloxymethyl)benzene

: 934243-71-7
1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / t-BuONa / Pd(dba)3*CHCl₃ / toluene / 5 h / 50 °C

2: 98 percent / DIBAL-H / CH₂Cl₂; hexane / 0.5 h / -78 - 20 °C

With diisobutylaluminium hydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium chloroform complex; In hexane; dichloromethane; toluene;
DOI:10.1021/ja070071z

Reference yield:

: 934243-68-2
1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-2-deoxy-3-O-(triethylsilyl)-D-arabino-1-hexenitol

: 934243-71-7
1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuLi / tetrahydrofuran; pentane / -78 - -50 °C

1.2: 89 percent / tetrahydrofuran; pentane / 1 h / -72 - 20 °C

2.1: 84 percent / H₂O / [RuCl₂(p-cymene)]2 / benzene; acetonitrile / 1 h / 20 °C

3.1: 82 percent / t-BuONa / Pd(dba)3*CHCl₃ / toluene / 5 h / 50 °C

4.1: 98 percent / DIBAL-H / CH₂Cl₂; hexane / 0.5 h / -78 - 20 °C

With water; tert.-butyl lithium; diisobutylaluminium hydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium chloroform complex; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In tetrahydrofuran; hexane; dichloromethane; toluene; acetonitrile; pentane; benzene;
DOI:10.1021/ja070071z

Reference yield:

: 934243-69-3
1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-2-deoxy-1-C-(dimethyl(silyl))-3-O-(triethylsilyl)-D-arabino-1-hexenitol

: 934243-71-7
1,5-anhydro-4,6-O-[bis(1,1-dimethylethyl)silylene]-1-C-[2',4'-bis(phenylmethoxy)-6'-(hydroxymethyl)phenyl]-2-deoxy-3-O-triethylsilyl-D-arabino-1-hexenitol

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / H₂O / [RuCl₂(p-cymene)]2 / benzene; acetonitrile / 1 h / 20 °C

2: 82 percent / t-BuONa / Pd(dba)3*CHCl₃ / toluene / 5 h / 50 °C

3: 98 percent / DIBAL-H / CH₂Cl₂; hexane / 0.5 h / -78 - 20 °C

With water; diisobutylaluminium hydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium chloroform complex; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In hexane; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1021/ja070071z