(S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate

Base Information

• Chemical Name: (S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate
• CAS No.: 1446270-33-2
• Molecular Formula: C₁₄H₁₆N₂O₃S₂
• Molecular Weight: 324.425
• Mol file: 1446270-33-2.mol

Synonyms:(S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate

Chemical Property of (S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate

There total 2 articles about (S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

carbon disulfide (75-15-0,12122-00-8) + L-homoserine lactone hydrochloride (2185-03-7) + N-(p-tolyl)-2-chloroacetamide (16634-82-5) → (S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate (1446270-33-2)

Guidance literature:

carbon disulfide; L-homoserine lactone hydrochloride; With sodium phosphate dodecahydrate; In acetone; at 20 ℃; for 0.5h;

N-(p-tolyl)-2-chloroacetamide; In acetone; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2013.05.035

Reference yield:

p-toluidine (106-49-0,12221-03-3) → (S)-2-oxo-2-(p-tolylamino)ethyl (2-oxotetrahydrofuran-3-yl)carbamodithioate (1446270-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: sodium phosphate dodecahydrate / acetone / 0.5 h

2.2: 0.5 h / 20 °C

With sodium phosphate dodecahydrate; potassium carbonate; In acetone;

DOI:10.1016/j.ejmech.2015.02.026

upstream raw materials:

carbon disulfide

L-homoserine lactone hydrochloride

N-(p-tolyl)-2-chloroacetamide

p-toluidine