2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide

Base Information

• Chemical Name: 2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide
• CAS No.: 1161361-81-4
• Molecular Formula: C₂₄H₂₄BrN₃O
• Molecular Weight: 450.378
• Mol file: 1161361-81-4.mol

Synonyms:2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide

Chemical Property of 2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide

There total 1 articles about 2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-bromo-1,2,3,4-tetrahydroisoquinoline (17680-55-6) + 4-(2-methylpyridin-4-yl)phenylamine (216059-91-5) + 2-Bromopropionyl chloride (7148-74-5) → 2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide (1161361-81-4)

Guidance literature:

4-(2-methylpyridin-4-yl)phenylamine; 2-Bromopropionyl chloride; With triethylamine; In dichloromethane; for 0.166667h;

7-bromo-1,2,3,4-tetrahydroisoquinoline; In dichloromethane;

Reference yield:

2-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide (1161361-81-4) + 2-methylpyridine-4-boronic acid (579476-63-4) → 2-(7-(2-methylpyridin-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide (1161361-82-5)

Guidance literature:

With potassium phosphate; bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; In toluene; at 90 ℃; for 1h;

upstream raw materials:

7-bromo-1,2,3,4-tetrahydroisoquinoline

4-(2-methylpyridin-4-yl)phenylamine

2-Bromopropionyl chloride

Downstream raw materials:

2-(7-(2-methylpyridin-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide