(E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

Base Information

Chemical Name:(E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one
CAS No.:1449603-71-7
Molecular Formula:C₁₅H₁₈N₂O₄
Molecular Weight:290.319
Hs Code.:

Synonyms:(E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

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Technology Process of (E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

There total 1 articles about (E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: methyl 4-(hydroxyimino)-4-(3-((4-methoxybenzyl)amino)oxetan-3-yl)butanoate

: 1449603-71-7
(E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 23h; Inert atmosphere;
DOI:10.1021/ol401705a

Reference yield: 93.0%

: 1449603-71-7
(E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

: 1449603-72-8,1449603-77-3,1449603-78-4
9-amino-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

Guidance literature:: With hydrogen; In ethanol; at 20 ℃; for 9h;
DOI:10.1021/ol401705a

Reference yield:

: 1449603-71-7
(E)-9-(hydroxyimino)-5-(4-methoxybenzyl)-2-oxa-5-azaspiro[3.5]nonan-6-one

: (+)-2-(5-(4-methoxybenzyl)-6-oxo-2-oxa-5-azaspiro[3.5]nonan-9-yl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / ethanol / 9 h / 20 °C

2: Chiralpak AD / isopropyl alcohol; n-heptane / Resolution of racemate

3: triethylamine / tetrahydrofuran / 2.25 h / 0 - 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 75 °C / Inert atmosphere

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; ethanol; n-heptane; isopropyl alcohol;
DOI:10.1021/ol401705a