8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Base Information

Chemical Name:8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine
CAS No.:479408-38-3
Molecular Formula:C₃₆H₃₆N₆O₇
Molecular Weight:664.718
Hs Code.:

8-(N-acetyl-2-amino-fluorene)-N<sup>2</sup>-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Synonyms:8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

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Chemical Property of 8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Chemical Property:

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Technology Process of 8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

There total 14 articles about 8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 479408-42-9
8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

: 479408-38-3
8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Guidance literature:: With cyclohexene; palladium on activated charcoal; In ethanol; for 3h; Heating;
DOI:10.1021/ol026474f

Reference yield:

: 13389-03-2
8-bromo-2'-deoxyguanosine

: 479408-38-3
8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / imidazole / dimethylformamide; tetrahydrofuran / 5 h / 20 °C

2: 78 percent / triphenylphosphine; diisopropyl azodicarboxylate / dioxane / 5 h / 20 °C

3: 94 percent / pyridine / 20 °C

4: 72 percent / sodium tert-butoxide; rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / tris(dibenzylideneaceton)-dipalladium / toluene / 1 h / 100 °C

5: triethylamine; 4-(dimethylamino)pyridine / pyridine / 5 h / 20 °C

6: 78 percent / hydrochloric acid / methanol / 20 °C

7: 97 percent / pyridine / 20 °C

8: 79 percent / tetra-n-butylammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

9: 88 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

With pyridine; 1H-imidazole; hydrogenchloride; dmap; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; triethylamine; triphenylphosphine; sodium t-butanolate; cyclohexene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; N,N-dimethyl-formamide; toluene; 4: Buchwald-Hartwig coupling;
DOI:10.1021/ol026474f

Reference yield:

: 479408-21-4
3',5'-O,O'-bis(tert-butyldimethylsilyl)-8-bromo-2'-deoxyguanosine

: 479408-38-3
8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / triphenylphosphine; diisopropyl azodicarboxylate / dioxane / 5 h / 20 °C

2: 94 percent / pyridine / 20 °C

3: 72 percent / sodium tert-butoxide; rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / tris(dibenzylideneaceton)-dipalladium / toluene / 1 h / 100 °C

4: triethylamine; 4-(dimethylamino)pyridine / pyridine / 5 h / 20 °C

5: 78 percent / hydrochloric acid / methanol / 20 °C

6: 97 percent / pyridine / 20 °C

7: 79 percent / tetra-n-butylammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

8: 88 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

With pyridine; hydrogenchloride; dmap; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; triethylamine; triphenylphosphine; sodium t-butanolate; cyclohexene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; toluene; 3: Buchwald-Hartwig coupling;
DOI:10.1021/ol026474f