4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

Base Information

Chemical Name:4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid
CAS No.:1364614-65-2
Molecular Formula:C₃₈H₃₇Cl₂F₂N₃O₆
Molecular Weight:740.631
Hs Code.:

4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

Synonyms:4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

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Chemical Property of 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

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Technology Process of 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

There total 1 articles about 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.94%

: 1229705-05-8
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-3-methoxybenzoic acid methyl ester

: trans-rac-ethyl 2-formylcyclopropanecarboxylate

: 1364614-65-2
4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-((1R,2R)-2-ethoxycarbonylcyclopropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

Guidance literature:: 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-3-methoxybenzoic acid methyl ester; trans-rac-ethyl 2-formylcyclopropanecarboxylate; With sodium tris(acetoxy)borohydride; acetic acid; at 20 ℃;

With lithium hydroxide; In tetrahydrofuran; at 20 - 50 ℃; for 72h;