Bisindolylmaleimide I HCl

Base Information

• Chemical Name: Bisindolylmaleimide I HCl
• CAS No.: 176504-36-2
• Molecular Formula: C25H24 N4 O2 . Cl H
• Molecular Weight: 0
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID00423558
• Mol file: 176504-36-2.mol

Synonyms:176504-36-2;Bisindolylmaleimide I HCl;Bisindolylmaleimide I, HCl;Bisindolylmaleimide I (hydrochloride);Bisindolylmaleimide I, Hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione hydrochloride;GF109203X (hydrochloride);Go 6850 (hydrochloride);Bisindolylmaleimide I hydrochloride;1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-, hydrochloride (1:1);BIM I;Bisindolylmaleimide I;2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl;BIS-I HCl;K00022;GF 109203X hydrochloride;Goe-6850;GO-6860 HCl;SCHEMBL1199513;GF-109203X HCl;DTXSID00423558;BHA50436;HY-13867A;3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;AKOS040747990;GF 109203X hydrochloride, >=95%;MS-28133;LS-193809;CS-0109350;G-6850;K00476;J-011200;2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide,hydrochloride;3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;hydrochloride

Chemical Property of Bisindolylmaleimide I HCl

Chemical Property:

• PSA: 73.62000
• LogP: 4.71940
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 448.1666037
• Heavy Atom Count: 32
• Complexity: 748

Purity/Quality:

98% ^*data from raw suppliers

GF 109203X hydrochloride ≥95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54.Cl
• Description: Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.
• Uses: GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.