(E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone

Base Information

• Chemical Name: (E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone
• CAS No.: 343572-93-0
• Molecular Formula: C₂₃H₁₈O₄
• Molecular Weight: 358.394
• Mol file: 343572-93-0.mol

Synonyms:(E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone

Chemical Property of (E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone

There total 1 articles about (E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperonal (120-57-0,30024-74-9) + 4'-benzyloxy-acetophenone (54696-05-8) → (E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone (343572-93-0)

Guidance literature:

With sodium hydroxide; In ethanol; for 1.5h; Ambient temperature;

DOI:10.1021/jm9606507

Reference yield:

potassium cyanide (151-50-8) + (E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone (343572-93-0) → 2-Benzo[1,3]dioxol-5-yl-4-(4-benzyloxy-phenyl)-4-oxo-butyronitrile (169804-38-0)

Guidance literature:

With acetic acid; In 2-ethoxy-ethanol; water; at 105 ℃; for 0.5h;

DOI:10.1021/jm9606507

Reference yield:

(E)-3-Benzo[1,3]dioxol-5-yl-1-(4-benzyloxy-phenyl)-propenone (343572-93-0) → 2-(benzo[1,3]dioxol-5-yl)-1-(4-benzyloxyphenyl)-4-oxobutyric acid methyl ester (169804-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / H₂O; 2-ethoxy-ethanol / 0.5 h / 105 °C

2: p-toluenesulfonic acid hydrate / dioxane / Heating

With toluene-4-sulfonic acid; acetic acid; In 1,4-dioxane; 2-ethoxy-ethanol; water;

DOI:10.1021/jm9606507

upstream raw materials:

piperonal

4'-benzyloxy-acetophenone

Downstream raw materials:

2-Benzo[1,3]dioxol-5-yl-4-(4-benzyloxy-phenyl)-4-oxo-butyronitrile

2-(benzo[1,3]dioxol-5-yl)-1-(4-benzyloxyphenyl)-4-oxobutyric acid methyl ester