tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane

Base Information

• Chemical Name: tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane
• CAS No.: 1004999-97-6
• Molecular Formula: C₂₁H₃₅IO₅Si
• Molecular Weight: 522.496
• Mol file: 1004999-97-6.mol

Synonyms:tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane

Chemical Property of tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane

There total 1 articles about tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H36O6Si (1004999-96-5) → tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane (1004999-97-6)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.11.037

Reference yield: 87.0%

tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane (1004999-97-6) → C21H34O5Si (1004999-98-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.11.037

Reference yield:

tert-butyl(((2S,3R,4R)-2-(iodomethyl)-6-methoxy-3-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl)oxy)dimethylsilane (1004999-97-6) → (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-5-hydroxy-2-((4-methoxybenzyl)oxy)cyclohexanone (1440947-82-9) + (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-5-hydroxy-2-((4-methoxybenzyl)oxy)cyclohexanone (1440947-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: mercury(II) trifluoroacetate / acetone / 16 h / 20 °C / pH 4.8 / Inert atmosphere

With potassium tert-butylate; mercury(II) trifluoroacetate; In tetrahydrofuran; acetone;

DOI:10.1002/chem.201203284

upstream raw materials:

C₂₁H₃₆O₆Si

Downstream raw materials:

C₂₁H₃₄O₅Si

(2S,3R)-3-((tert-butyldimethylsilyl)oxy)-5-hydroxy-2-((4-methoxybenzyl)oxy)cyclohexanone

(2S,3R)-3-((tert-butyldimethylsilyl)oxy)-5-hydroxy-2-((4-methoxybenzyl)oxy)cyclohexanone