(2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone

Base Information

• Chemical Name: (2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone
• CAS No.: 444808-38-2
• Molecular Formula: C₁₈H₁₃Cl₂NOS
• Molecular Weight: 362.279

Synonyms:(2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone

Chemical Property of (2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone

Chemical Property:

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Technology Process of (2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone

There total 2 articles about (2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-isocyanatomethanesulfonyl-4-methyl-benzene (10564-55-3) + (E)-1-(2,4-Dichloro-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone (935289-23-9) → (2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone (444808-38-2)

Guidance literature:

With sodium hydride; In diethyl ether; dimethyl sulfoxide; at 20 ℃; for 0.5h;

DOI:10.1021/jm011087h

Reference yield:

4-(Methylthio)benzaldehyde (3446-89-7) → (2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone (444808-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / aq. NaOH / 1 h

2: 74 percent / NaH / dimethylsulfoxide; diethyl ether / 0.5 h / 20 °C

With sodium hydroxide; sodium hydride; In diethyl ether; dimethyl sulfoxide;

DOI:10.1021/jm011087h

Reference yield: 94.0%

(2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanone (444808-38-2) → (2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanol (444808-48-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; for 12h; Heating;

DOI:10.1021/jm011087h

upstream raw materials:

1-isocyanatomethanesulfonyl-4-methyl-benzene

(E)-1-(2,4-Dichloro-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone

4-(Methylthio)benzaldehyde

Downstream raw materials:

(2,4-dichloro-phenyl)-[4-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-methanol

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