(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide

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Chemical Name:(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide
CAS No.:405262-88-6
Molecular Formula:C₂₆H₂₄ClN₅O₄S
Molecular Weight:538.027
Hs Code.:

Synonyms:(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide

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Chemical Property of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide

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Technology Process of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide

There total 3 articles about (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 405262-65-9
(E)-1-Phenyl-pent-1-ene-2-sulfonic acid amide

: 405262-88-6
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide

Guidance literature:: (E)-1-Phenyl-pent-1-ene-2-sulfonic acid amide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1248/cpb.49.1593

Reference yield:

: 826-18-6
1-pentenylbenzene

: 405262-88-6
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: SO₂Cl₂ / dimethylformamide / 0.5 h / 80 °C

2.1: 29 percent aq. NH₃ / tetrahydrofuran / 12 h / 20 °C

3.1: NaH / dimethylformamide / 0.17 h / 20 °C

3.2: 72 percent / dimethylformamide / 2 h / 20 °C

With ammonium hydroxide; sulfuryl dichloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1593

Reference yield:

: (E)-1-Phenyl-pent-1-enesulfonyl chloride

: 405262-88-6
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenyl-1-propylethenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 29 percent aq. NH₃ / tetrahydrofuran / 12 h / 20 °C

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: 72 percent / dimethylformamide / 2 h / 20 °C

With ammonium hydroxide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1593