N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester
• CAS No.: 1178549-19-3
• Molecular Formula: C₂₀H₂₈N₂O₆
• Molecular Weight: 392.452
• Mol file: 1178549-19-3.mol

Synonyms:N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester

Chemical Property of N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester

There total 1 articles about N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

glycine benzyl ester p-toluenesulfonic acid salt (1738-76-7) + (2S,4R)-1-(tert-butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid (83624-01-5) → N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester (1178549-19-3)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1021/ja800225k

Reference yield:

N-tert-butoxycarbonyl-(2S,4R)-4-methoxyprolylglycine benzyl ester (1178549-19-3) → C15H20N2O4*ClH

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 25h;

DOI:10.1021/ja800225k

upstream raw materials:

glycine benzyl ester p-toluenesulfonic acid salt

(2S,4R)-1-(tert-butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid