Technology Process of bispyrido<3',2':6,7>cyclohepta<1,2-b:2',1'-e>pyridine-3,8,13-tricarboxylic acid, 2,14-bis<<(3,4-dimethoxyphenyl)methyl>amino>-5,6,7,9,10,11-hexahydro-, triethyl ester
There total 12 articles about bispyrido<3',2':6,7>cyclohepta<1,2-b:2',1'-e>pyridine-3,8,13-tricarboxylic acid, 2,14-bis<<(3,4-dimethoxyphenyl)methyl>amino>-5,6,7,9,10,11-hexahydro-, triethyl ester which
guide to synthetic route it.
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synthetic route:
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154796-24-4
bispyrido<3',2':6,7>cyclohepta<1,2-b:2',1'-e>pyridine-3,8,13-tricarboxylic acid, 2,14-bis<<(3,4-dimethoxyphenyl)methyl>amino>-5,6,7,9,10,11-hexahydro-, triethyl ester
- Guidance literature:
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Multi-step reaction with 4 steps
1: 100 percent / TsOH / tetrahydrofuran / 50 °C
2: 2.) HCl / 1.) THF, from -78 deg C to RT, 36 h, 2.) THF, 6 h
3: 2.) HCl / 1.) THF, reflux, 24 h, 2.) THF, overnight
4: 50 percent / ammonium acetate / acetic acid / 10 h / Heating
With
ammonium acetate; hydrogenchloride; toluene-4-sulfonic acid;
In
tetrahydrofuran; acetic acid;
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154796-24-4
bispyrido<3',2':6,7>cyclohepta<1,2-b:2',1'-e>pyridine-3,8,13-tricarboxylic acid, 2,14-bis<<(3,4-dimethoxyphenyl)methyl>amino>-5,6,7,9,10,11-hexahydro-, triethyl ester
- Guidance literature:
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Multi-step reaction with 3 steps
1: 2.) HCl / 1.) THF, from -78 deg C to RT, 36 h, 2.) THF, 6 h
2: 2.) HCl / 1.) THF, reflux, 24 h, 2.) THF, overnight
3: 50 percent / ammonium acetate / acetic acid / 10 h / Heating
With
ammonium acetate; hydrogenchloride;
In
acetic acid;
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-
154796-24-4
bispyrido<3',2':6,7>cyclohepta<1,2-b:2',1'-e>pyridine-3,8,13-tricarboxylic acid, 2,14-bis<<(3,4-dimethoxyphenyl)methyl>amino>-5,6,7,9,10,11-hexahydro-, triethyl ester
- Guidance literature:
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Multi-step reaction with 5 steps
1: 1.) OsO4, 2.) NaIO4 / 1.) H2O, THF, t-BuOH, 10 min, 2.) H2O, THF, t-BuOH, 30 h
2: 100 percent / TsOH / tetrahydrofuran / 50 °C
3: 2.) HCl / 1.) THF, from -78 deg C to RT, 36 h, 2.) THF, 6 h
4: 2.) HCl / 1.) THF, reflux, 24 h, 2.) THF, overnight
5: 50 percent / ammonium acetate / acetic acid / 10 h / Heating
With
ammonium acetate; hydrogenchloride; sodium periodate; osmium(VIII) oxide; toluene-4-sulfonic acid;
In
tetrahydrofuran; acetic acid;
