2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol

Base Information

Chemical Name:2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol
CAS No.:154085-00-4
Molecular Formula:C₂₈H₄₀O₃Si
Molecular Weight:452.709
Hs Code.:

Synonyms:2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol

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Chemical Property of 2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol

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Technology Process of 2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol

There total 6 articles about 2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154085-01-5
2-<(2-benzyloxymethyl)-1-(tert-butyldimethylsiloxy-2-cyclohexen-1-yl)ethyl>phenyl trifluoromethanesulfonate

: 4aβ-benzyloxymethyl-10aβ-tert-butyldimethylsilyloxy-1,4,4a,9,10,10a-hexahydrophenanthrene

: 4aβ-benzyloxymethyl-10aβ-tert-butyldimethylsilyloxy-1,2,4a,9,10,10a-hexahydrophenanthrene

: 154085-00-4
2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol

Guidance literature:: With potassium acetate; Pd(1,2-bis(diphenylphosphino)butane); In N,N-dimethyl acetamide; at 120 ℃; for 30h; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4020(01)80759-6

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 154085-00-4
2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / tert-BuLi, CuCN / pentane; tetrahydrofuran / from -78 to 0 degC

2: 94 percent / n-BuLi / tetrahydrofuran / 0.17 h / -78 °C

3: 84 percent / tetrahydrofuran; various solvent(s) / from -78 to 23 degC

With n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; pentane;
DOI:10.1016/S0040-4020(01)80759-6

Reference yield:

: 70156-98-8
6-bromo-1,4-dioxaspiro[4,5]dec-6-ene

: 154085-00-4
2-{2-[2-Benzyloxymethyl-1-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-ethyl}-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / tert-BuLi, CuCN / pentane; tetrahydrofuran / from -78 to 0 degC

2: 94 percent / n-BuLi / tetrahydrofuran / 0.17 h / -78 °C

3: 84 percent / tetrahydrofuran; various solvent(s) / from -78 to 23 degC

With n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; pentane;
DOI:10.1016/S0040-4020(01)80759-6