bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate

Base Information

• Chemical Name: bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate
• CAS No.: 1622913-85-2
• Molecular Formula: C₅₄H₆₄Cl₂F₂N₂O₆
• Molecular Weight: 946.015
• Mol file: 1622913-85-2.mol

Synonyms:bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate

Chemical Property of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate

There total 2 articles about bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,12-dodecanedioyl dichloride (4834-98-4) + haloperidol (52-86-8) → bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate (1622913-85-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.06.079

Reference yield:

1,12-dodecanedioic acid (693-23-2) → bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidine-4-yl} dodecanedioate (1622913-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2014.06.079

upstream raw materials:

1,12-dodecanedioic acid

1,12-dodecanedioyl dichloride

haloperidol