Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester

Base Information

Chemical Name:Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester
CAS No.:218792-68-8
Molecular Formula:C₃₄H₄₁NO₅Si
Molecular Weight:571.789
Hs Code.:

Synonyms:Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester

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Chemical Property of Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester

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Technology Process of Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester

There total 1 articles about Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 108-24-7
acetic anhydride

: (3S,6S,8S,8aS)-8-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-6-hydroxy-hexahydro-indolizin-5-one

: 218792-68-8
Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester

Guidance literature:: With pyridine; for 1h; Ambient temperature;
DOI:10.1016/S0960-894X(98)00500-9

Reference yield: 78.0%

: 218792-68-8
Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester

: 218792-55-3
Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-hydroxymethyl-5-oxo-octahydro-indolizin-6-yl ester

Guidance literature:: With pyridine; hydrogen fluoride; at 0 ℃; for 4h;
DOI:10.1016/S0960-894X(98)00500-9

Reference yield:

: 218792-68-8
Acetic acid (3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yl ester

: [(3S,6S,8S,8aS)-8-Hydroxy-5-oxo-3-((2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxymethyl)-octahydro-indolizin-6-yloxy]-phenyl-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / HF, pyridine / 4 h / 0 °C

2: 70 percent / CuBr₂, Bu₄NBr / CH₂Cl₂ / 16 h / Ambient temperature

3: 91 percent / NaOMe / 1 h / Ambient temperature

4: 93 percent / Rh₂(OAc)4 / 12 h / Ambient temperature

5: 100 percent / H₂ / Pd(OH)2/C / methanol / 12 h / Ambient temperature

6: 100 percent / 0.1 N aq. NaOH / 3 h / Ambient temperature

With pyridine; dirhodium tetraacetate; sodium hydroxide; hydrogen fluoride; tetrabutylammomium bromide; hydrogen; sodium methylate; copper(ll) bromide; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00500-9