Benzamide, 3,4,5-tris(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

Base Information

Chemical Name:Benzamide, 3,4,5-tris(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-
CAS No.:176379-00-3
Molecular Formula:C₂₄H₂₂N₄O₉
Molecular Weight:510.46
Hs Code.:
Mol file:176379-00-3.mol

Synonyms:Benzamide, 3,4,5-tris(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 3,4,5-tris(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

Chemical Property:

PSA：181.51000
LogP:2.11180

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzamide, 3,4,5-tris(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

There total 6 articles about Benzamide, 3,4,5-tris(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.6%

: 6635-24-1
3,4,5-triacetoxybenzoic acid

: 50786-93-1
5,6-diamino-3-methyl-1-phenyluracil

: 176379-00-3
acetic acid 2,3-diacetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester

Guidance literature:: With triethylamine; Diphenylphosphinic chloride; In dichloromethane; at 0 ℃;
DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

: 42212-19-1
6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione

: 176379-00-3
acetic acid 2,3-diacetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaNO₂; aq. HCl / 20 °C

2: H₂ / 5 percent Pd/C / methanol

3: Et₃N; diphenylphosphoryl chloride / CH₂Cl₂

With hydrogenchloride; hydrogen; triethylamine; sodium nitrite; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1248/cpb.51.309

Reference yield:

: 6-amino-3-methyl-5-nitro-1-phenyl-1H-pyrimidine-2,4-dione

: 176379-00-3
acetic acid 2,3-diacetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / methanol

2: Et₃N; diphenylphosphoryl chloride / CH₂Cl₂

With hydrogen; triethylamine; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1248/cpb.51.309