(S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate

Base Information

Chemical Name:(S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate
CAS No.:1353255-10-3
Molecular Formula:C₄₆H₃₉F₂N₅O₃
Molecular Weight:747.844
Hs Code.:

Synonyms:(S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate

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Chemical Property of (S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate

Chemical Property:

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Technology Process of (S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate

There total 10 articles about (S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353254-13-3
3-pyridin-4-yl-1-trityl-1H-indazole-5-carboxylic acid

: (S)-methyl 2-((R)-3-aminopiperidin-1-yl)-2-(2,6-difluorophenyl)acetate bis-hydrochloride

: 1353255-10-3
(S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: ethyl 3-bromo-1H-indazole-5-carboxylate

: 1353255-10-3
(S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 5 - 10 °C

1.2: 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 50 °C

2.2: pH ~ 4

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 80 °C / Inert atmosphere

3.2: pH 7

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 18 h / 20 °C

With sodium hydride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1353255-12-5
ethyl 1H-indazole-5-carboxylate hydrochloride

: 1353255-10-3
(S)-methyl 2-(2,6-difluorophenyl)-2-((R)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / ethanol / 18 h / 20 °C

1.2: pH 10 - 11 / Cooling with ice

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 5 - 10 °C

2.2: 20 °C

3.1: lithium hydroxide / tetrahydrofuran / 50 °C

3.2: pH ~ 4

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 80 °C / Inert atmosphere

4.2: pH 7

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 18 h / 20 °C

With bromine; sodium hydride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;