Technology Process of 2-(tert-butoxycarbonylamino)-2-{(4R,5S)-2,2-dimethyl-5-[(E)-1-(4-methylphenylsulfonyl)tetradecyl]-1,3-dioxolan-4-yl}-1-ethanol
There total 9 articles about 2-(tert-butoxycarbonylamino)-2-{(4R,5S)-2,2-dimethyl-5-[(E)-1-(4-methylphenylsulfonyl)tetradecyl]-1,3-dioxolan-4-yl}-1-ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium dihydroxide;
In
ethanol;
at 20 ℃;
for 16h;
DOI:10.1021/jo034157w
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 88 percent / N-bromosuccinimide; water / toluene / 0.25 h / 20 °C
2: 83 percent / K2CO3 / methanol / 1.75 h / 0 - 20 °C
3: 85 percent / NaN3; NH4Cl / methanol; H2O / 6 h / Heating
4: 87 percent / CSA / acetone / 1 h / 20 °C
5: 1-tridecene / CH2Cl2 / 1.08 h / 0 °C
6: 930 mg / SnCl4 / CH2Cl2 / 0.17 h / 0 °C
7: 82 percent / 2KHSO5*KHSO4*K2SO4 / tetrahydrofuran; methanol; H2O / 4.5 h / 0 - 20 °C
8: 71 percent / H2 / Pd(OH)2/C / ethanol / 16 h / 20 °C
With
potassium sulfate; potassium hydrogensulfate; N-Bromosuccinimide; potassium peroxomonosulfate; sodium azide; 1-tridecene; camphor-10-sulfonic acid; water; hydrogen; tin(IV) chloride; potassium carbonate; ammonium chloride;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; toluene;
5: Pummerer reaction;
DOI:10.1021/jo034157w
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 92 percent / DIBAL-H / tetrahydrofuran; toluene / 0.58 h / -78 °C
2: 88 percent / N-bromosuccinimide; water / toluene / 0.25 h / 20 °C
3: 83 percent / K2CO3 / methanol / 1.75 h / 0 - 20 °C
4: 85 percent / NaN3; NH4Cl / methanol; H2O / 6 h / Heating
5: 87 percent / CSA / acetone / 1 h / 20 °C
6: 1-tridecene / CH2Cl2 / 1.08 h / 0 °C
7: 930 mg / SnCl4 / CH2Cl2 / 0.17 h / 0 °C
8: 82 percent / 2KHSO5*KHSO4*K2SO4 / tetrahydrofuran; methanol; H2O / 4.5 h / 0 - 20 °C
9: 71 percent / H2 / Pd(OH)2/C / ethanol / 16 h / 20 °C
With
potassium sulfate; potassium hydrogensulfate; N-Bromosuccinimide; potassium peroxomonosulfate; sodium azide; 1-tridecene; camphor-10-sulfonic acid; water; hydrogen; tin(IV) chloride; diisobutylaluminium hydride; potassium carbonate; ammonium chloride;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; toluene;
6: Pummerer reaction;
DOI:10.1021/jo034157w