N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide

Base Information

Chemical Name:N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide
CAS No.:1264534-20-4
Molecular Formula:C₂₄H₂₆N₄O₂S₂
Molecular Weight:466.628
Hs Code.:

Synonyms:N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide

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Chemical Property of N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide

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Technology Process of N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide

There total 5 articles about N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1264534-49-7
N₁,N₃-dimethyl-N₁-[2-(thiophen-2-yl)quinazolin-4-yl]propane-1,3-diamine

: 98-59-9
p-toluenesulfonyl chloride

: 1264534-20-4
N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃;
DOI:10.1021/jm1008902

Reference yield:

: 1264534-45-3
tert-butyl methyl(3-{methyl[2-(thiophen-2-yl)-quinazolin-4-yl]amino}propyl)carbamate

: 1264534-20-4
N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 16 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/jm1008902

Reference yield:

: 1264534-41-9
tert-butyl 3-[(2-chloroquinazolin-4-yl)(methyl)-amino]propyl(methyl)carbamate

: 1264534-20-4
N,4-dimethyl-N-(3-{methyl[2-(thiophen-2-yl)quinazolin-4-yl]amino}propyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / Inert atmosphere; Reflux

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 16 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; 1: Suzuki coupling;
DOI:10.1021/jm1008902