(R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

Base Information

Chemical Name:(R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime
CAS No.:1373161-23-9
Molecular Formula:C₃₂H₄₁NO₂Si
Molecular Weight:499.769
Hs Code.:

Synonyms:(R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

Suppliers and Price of (R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

There total 3 articles about (R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1373161-09-1
2,7-di-tert-butyl-9H-9-methylsilafluorene

: 73826-09-2
rac-propan-2-one-O-(2-hydroxy-2-phenylethyl)oxime

: 338464-39-4
(S)-propan-2-one-O-(2-hydroxy-2-phenylethyl)oxime

: 1373161-25-1
(R)-propan-2-one-O-(2-hydroxy-2-phenylethyl)oxime

: 1373161-23-9
(R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

Guidance literature:: With (3aR,8aR)-6-t-butyl-2,2-dimethyl-4,4,8,8-tetra(naphthalen-2-yl)tetrahydro[1,3]dioxolo[4,5-e]-[1,3,2]dioxaphosphepine; copper(l) chloride; sodium t-butanolate; In toluene; at 20 ℃; for 40h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.06.102

Reference yield:

: 4388-14-1
α-Aminooxymethyl-benzylalkohol

: 338464-39-4
(S)-propan-2-one-O-(2-hydroxy-2-phenylethyl)oxime

: 1373161-25-1
(R)-propan-2-one-O-(2-hydroxy-2-phenylethyl)oxime

: 1373161-23-9
(R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; acetic acid / ethanol / Reflux; Inert atmosphere

2: (3aR,8aR)-6-t-butyl-2,2-dimethyl-4,4,8,8-tetra(naphthalen-2-yl)tetrahydro[1,3]dioxolo[4,5-e]-[1,3,2]dioxaphosphepine; copper(l) chloride; sodium t-butanolate / toluene / 40 h / 20 °C / Inert atmosphere

With pyridine; (3aR,8aR)-6-t-butyl-2,2-dimethyl-4,4,8,8-tetra(naphthalen-2-yl)tetrahydro[1,3]dioxolo[4,5-e]-[1,3,2]dioxaphosphepine; acetic acid; copper(l) chloride; sodium t-butanolate; In ethanol; toluene;
DOI:10.1016/j.tet.2011.06.102

Reference yield:

: 492441-96-0
rac-tert-butyl 2-hydroxy-2-phenylethoxycarbamate

: 338464-39-4
(S)-propan-2-one-O-(2-hydroxy-2-phenylethyl)oxime

: 1373161-25-1
(R)-propan-2-one-O-(2-hydroxy-2-phenylethyl)oxime

: 1373161-23-9
(R)-2-propanone-O-2-(2,7-di-tert-butyl-9-methyl-9-silafluorenyloxy-2-phenylethyl)oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / toluene / 1 h / 60 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere; Saturated solution

2.1: pyridine; acetic acid / ethanol / Reflux; Inert atmosphere

3.1: (3aR,8aR)-6-t-butyl-2,2-dimethyl-4,4,8,8-tetra(naphthalen-2-yl)tetrahydro[1,3]dioxolo[4,5-e]-[1,3,2]dioxaphosphepine; copper(l) chloride; sodium t-butanolate / toluene / 40 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; (3aR,8aR)-6-t-butyl-2,2-dimethyl-4,4,8,8-tetra(naphthalen-2-yl)tetrahydro[1,3]dioxolo[4,5-e]-[1,3,2]dioxaphosphepine; water; acetic acid; copper(l) chloride; sodium t-butanolate; In ethanol; toluene;
DOI:10.1016/j.tet.2011.06.102