(1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

Base Information

Chemical Name:(1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate
CAS No.:1620084-94-7
Molecular Formula:C₃₄H₄₆N₂O₃
Molecular Weight:530.751
Hs Code.:

Synonyms:(1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

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Chemical Property of (1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

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Technology Process of (1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

There total 2 articles about (1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620084-99-2
(R)-1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid

: 180979-18-4,1346773-57-6
(1S,2S)-ethyl 2-aminocyclohexanecarboxylate hydrochloride

: 1620084-94-7
(1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 80789-69-1
1-(4-chlorophenyl)cyclopentane-1-carboxylic acid

: 1620084-94-7
(1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.17 h / 150 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate; triethylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;