C₃₈H₃₆Cl₃F₃N₂O₇

Base Information

• Chemical Name: C₃₈H₃₆Cl₃F₃N₂O₇
• CAS No.: 1401413-11-3
• Molecular Formula: C₃₈H₃₆Cl₃F₃N₂O₇
• Molecular Weight: 796.067
• Mol file: 1401413-11-3.mol

Synonyms:C₃₈H₃₆Cl₃F₃N₂O₇

Chemical Property of C₃₈H₃₆Cl₃F₃N₂O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₃₆Cl₃F₃N₂O₇

There total 12 articles about C₃₈H₃₆Cl₃F₃N₂O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C30H32Cl3NO7 + 2,2,2-trifluoro-N-phenyl-acetimidoyl chloride (61881-19-4) → C38H36Cl3F3N2O7 (1401413-11-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

D-glucosamine hydrochloride (14131-63-6) → C38H36Cl3F3N2O7 (1401413-11-3)

Guidance literature:

Multi-step reaction with 14 steps

1.1: sodium hydrogencarbonate / water / 0.5 h / 20 °C

1.2: 4.5 h / 20 °C

2.1: pyridine / 0 - 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C

4.1: zinc; acetic acid / dichloromethane; methanol / 1 h / 0 - 20 °C / Inert atmosphere

5.1: sodium methylate / dichloromethane; methanol / 2 h / 20 °C

5.2: pH ~ 7

6.1: potassium carbonate; triflic azide / zinc(II) chloride / dichloromethane; water; methanol / 20 °C

7.1: camphorsulfonic acid / toluene / 2 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

9.1: trifluorormethanesulfonic acid; triethylsilane / dichloromethane / 1 h / -78 °C

10.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

10.2: 2 h / 20 °C

11.1: sodium hydroxide; trimethylphosphane / water; tetrahydrofuran / 20 °C

12.1: sodium hydrogencarbonate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

13.1: water; ammonium cerium (IV) nitrate / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

14.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / 0 - 20 °C

With pyridine; triethylsilane; ammonium cerium (IV) nitrate; trifluorormethanesulfonic acid; triflic azide; boron trifluoride diethyl etherate; water; sodium methylate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; zinc; trimethylphosphane; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranose (122210-05-3) → C38H36Cl3F3N2O7 (1401413-11-3)

Guidance literature:

Multi-step reaction with 12 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C

2.1: zinc; acetic acid / dichloromethane; methanol / 1 h / 0 - 20 °C / Inert atmosphere

3.1: sodium methylate / dichloromethane; methanol / 2 h / 20 °C

3.2: pH ~ 7

4.1: potassium carbonate; triflic azide / zinc(II) chloride / dichloromethane; water; methanol / 20 °C

5.1: camphorsulfonic acid / toluene / 2 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

7.1: trifluorormethanesulfonic acid; triethylsilane / dichloromethane / 1 h / -78 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

8.2: 2 h / 20 °C

9.1: sodium hydroxide; trimethylphosphane / water; tetrahydrofuran / 20 °C

10.1: sodium hydrogencarbonate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

11.1: water; ammonium cerium (IV) nitrate / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / 0 - 20 °C

With triethylsilane; ammonium cerium (IV) nitrate; trifluorormethanesulfonic acid; triflic azide; boron trifluoride diethyl etherate; water; sodium methylate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; zinc; trimethylphosphane; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

upstream raw materials:

2,2,2-trifluoro-N-phenyl-acetimidoyl chloride

D-glucosamine hydrochloride

1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranose

4-methoxyphenyl 2-azido-3,4,6-tri-O-benzyl-2-deoxy-α-D-glucopyranoside