2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid

Base Information

• Chemical Name: 2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid
• CAS No.: 1005752-07-7
• Molecular Formula: C₁₉H₂₄N₂O₃
• Molecular Weight: 328.411

Synonyms:2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid

Chemical Property of 2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid

Chemical Property:

Purity/Quality:

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Technology Process of 2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid

There total 1 articles about 2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid ethyl ester (1005751-02-9) → 2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid (1005752-07-7)

Guidance literature:

2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid ethyl ester; With methanol; lithium hydroxide; water; In tetrahydrofuran; for 2h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran; methanol; Product distribution / selectivity;

Reference yield: 84.0%

2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid (1005752-07-7) + 4-tert-butyl 1-methyl L-aspartate hydrochloride (2673-19-0,63329-02-2) → (S)-2-{2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyrylamino}-succinic acid 4-tert-butyl ester 1-methyl ester (1005751-84-7)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

Reference yield:

(3S)-3-amino-5-(tert-butoxy)-2-hydroxy-5-oxopentyl 2,6-dichlorobenzoate (847945-49-7) + 2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid (1005752-07-7) → 2,6-dichloro-benzoic acid (S)-4-tert-butoxycarbonyl-3-{2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyrylamino}-2-hydroxy-butyl ester (1005751-72-3)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

upstream raw materials:

2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyric acid ethyl ester

Downstream raw materials:

2,6-dichloro-benzoic acid (S)-4-tert-butoxycarbonyl-3-{2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyrylamino}-2-hydroxy-butyl ester

(S)-3-{2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyrylamino}-4-hydroxy-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid tert-butyl ester

(S)-2-{2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyrylamino}-succinic acid 4-tert-butyl ester 1-methyl ester

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