7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

Base Information

Chemical Name:7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide
CAS No.:1203663-37-9
Molecular Formula:C₁₆H₁₃FIN₃O₃S
Molecular Weight:473.266
Hs Code.:

Synonyms:7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

Suppliers and Price of 7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

There total 8 articles about 7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1203663-38-0
7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic acid (2-vinyloxyethoxy)amide

: 1203663-37-9
7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

Guidance literature:: 7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic acid (2-vinyloxyethoxy)amide; With hydrogenchloride; water; In methanol; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1203662-85-4
7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic acid tert-butyl ester

: 1203663-37-9
7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

3: hydrogenchloride / methanol; water / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2017094

Reference yield:

: 1203662-53-6
7-fluorobenzo[d]isothiazole-6-carboxylic acid tert-butyl ester

: 1203663-37-9
7-[(2-fluoro-4-iodophenyl)amino]benzo[d]isothiazole-6-carboxylic (2-hydroxyethoxy)amide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4: hydrogenchloride / methanol; water / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2017094