((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Base Information

Chemical Name:((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate
CAS No.:1325653-74-4
Molecular Formula:C₂₈H₃₄O₇S
Molecular Weight:514.64
Hs Code.:

Synonyms:((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

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Chemical Property of ((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

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Technology Process of ((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

There total 7 articles about ((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 886747-44-0
4-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)butanal

: 1325653-69-7
(2R,3S)-3-(dimethyl(phenyl)silyl)-2-((trimethylsilyl)oxy)pent-4-en-1-yl 2,4,6-trimethylbenzenesulfonate

: 1325653-74-4
((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; benzene; at -78 ℃; for 2h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol201863b

Reference yield:

: 934560-37-9
5-(4-hydroxybutyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 1325653-74-4
((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C / Molecular sieve; Inert atmosphere

2: trimethylsilyl trifluoromethanesulfonate / dichloromethane; benzene / 2 h / -78 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; pyridinium chlorochromate; In dichloromethane; benzene;
DOI:10.1021/ol201863b

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 1325653-74-4
((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / dichloromethane / 72 h / 20 °C / Inert atmosphere

2: pyridine / tetrahydrofuran / 12 h / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane; benzene / 2 h / -78 °C / Inert atmosphere

With pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol201863b