malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester

Base Information

• Chemical Name: malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester
• CAS No.: 364633-82-9
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 364633-82-9.mol

Synonyms:malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester

Chemical Property of malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester

There total 3 articles about malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-methyl-2-buten-1-ol (556-82-1) + malonic acid (R)-(+)-1-phenylethylamide (364633-81-8) → malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester (364633-82-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/S0957-4166(01)00232-4

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester (364633-82-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 h / Heating

2: aq. NaOH / 2 h / Heating

3: 67 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 6 h / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/S0957-4166(01)00232-4

Reference yield:

N-(1-phenyl-ethyl)-malonamic acid ethyl ester (668999-97-1) → malonic acid [(R)-(+)-1-phenylethylamide]-3-methyl-2-buten-1-yl ester (364633-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 2 h / Heating

2: 67 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 6 h / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/S0957-4166(01)00232-4

upstream raw materials:

3-methyl-2-buten-1-ol

malonic acid (R)-(+)-1-phenylethylamide

(R)-1-phenyl-ethyl-amine

N-(1-phenyl-ethyl)-malonamic acid ethyl ester