3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

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Chemical Name:3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide
CAS No.:1446247-11-5
Molecular Formula:C₂₆H₃₁N₇O₃S
Molecular Weight:521.643
Hs Code.:

Synonyms:3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

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Chemical Property of 3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

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Technology Process of 3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

There total 9 articles about 3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1446247-10-4
3-(4-aminophenyl)-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

: 622-58-2,374675-64-6
p-Tolylisocyanate

: 1446247-11-5
3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2.33h;

Reference yield:

: 1446247-08-0
3-(4-nitrophenyl)-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

: 1446247-11-5
3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 24 h / 4137.29 Torr / Autoclave

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 2.33 h / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 605661-26-5
2-[amino(4-nitrophenyl)methylene]malononitrile

: 1446247-11-5
3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: O,O-Diethyl hydrogen phosphorodithioate / ethanol; water / 100 °C / Inert atmosphere

2.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3.2: 20 °C

4.1: sulfuric acid / 1.83 h / 20 - 45 °C

4.2: 0.5 h / Cooling with ice

5.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 24 h / 4137.29 Torr / Autoclave

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 2.33 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; O,O-Diethyl hydrogen phosphorodithioate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;