(3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

Base Information

• Chemical Name: (3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate
• CAS No.: 1018909-84-6
• Molecular Formula: C₂₈H₃₉N₃O₅
• Molecular Weight: 497.635

Synonyms:(3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

Chemical Property of (3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

Chemical Property:

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Technology Process of (3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

There total 12 articles about (3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3R,4R)-tert-butyl 3-{{6-[benzyl(tert-butoxycarbonyl)amino]-4-methylpyridin-2-yl}methyl}-4-{(1S,4R)-4,7,7-trimethyl-3-oxo-oxabicyclo[2.2.1]heptane-1-carbonyloxy}pyrrolidine-1-carboxylate (1018909-82-4) → (3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate (1018909-84-6)

Guidance literature:

With sodium carbonate; In methanol; water; at 20 ℃; for 14h;

DOI:10.1021/ja910228a

Reference yield: 100.0%

(3R,4R)-tert-butyl 3-{{6'-[benzyl(tert-butoxycarbonyl)amino]-4'-methylpyridin-2'-yl}methyl}-4-{(1S,4R)-4',7',7'-trimethyl-3'-oxo-2'-oxabicyclo[2.2.1]heptane-1'-carbonyloxy}pyrrolidine-1-carboxylate → (3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate (1018909-84-6)

Guidance literature:

With water; sodium carbonate; In methanol; at 20 ℃; for 14h;

DOI:10.1021/jm100947x

Reference yield: 100.0%

→ (3'R,4'R)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate (1018909-84-6)

Guidance literature:

upstream raw materials:

(3R,4R)-tert-butyl 3-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)-4-(tert-butoxycarbonyloxy)pyrrolidine-1-carboxylate

benzyl bromide

(3R,4R)-tert-butyl 3-{{6-[benzyl(tert-butoxycarbonyl)amino]-4-methylpyridin-2-yl}methyl}-4-{(1S,4R)-4,7,7-trimethyl-3-oxo-oxabicyclo[2.2.1]heptane-1-carbonyloxy}pyrrolidine-1-carboxylate

N-(tert-butoxycarbonyl)-3-pyrroline

Downstream raw materials:

(3S,4R)-tert-butyl 3-azido-4-{{6-[benzyl(tert-butoxycarbonyl)amino]-4-methylpyridin-2-yl}methyl}-4-hydroxypyrrolidine-1-carboxylate

(3'S,4'R)-tert-butyl 3'-acetoxy-4'-{{6''-[benzyl(tert-butoxycarbonyl)amino]-4''-methylpyridin-2''-yl}methyl}pyrrolidine-1'-carboxylate

(3'R,4'R)-tert-butyl 3'-(allyloxy)-4'-{{6''-[benzyl(tert-butoxycarbonyl)amino]-4''-methylpyridin-2''-yl}methyl}pyrrolidine-1'-carboxylate

C₃₂H₄₄FN₃O₅

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