(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate

Base Information

• Chemical Name: (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate
• CAS No.: 1253795-13-9
• Molecular Formula: C₁₉H₂₆IN₃O₈
• Molecular Weight: 551.335
• Mol file: 1253795-13-9.mol

Synonyms:(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate

Chemical Property of (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate

There total 1 articles about (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-N-Boc-Ala (15761-38-3) + C11H13IN2O5 (1305317-48-9) → (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate (1253795-13-9)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1002/chem.201000924

Reference yield: 52.0%

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate (1253795-13-9) → (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(4-methoxy-3-nitrophenyl)propanoate (1253795-14-0)

Guidance literature:

With palladium diacetate; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; CyJohnPhos; In 1,4-dioxane; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201000924

Reference yield: 40.0%

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate (1253795-13-9) → (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(4-hydroxy-3-nitrophenyl)propanoate (71026-62-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In dimethyl sulfoxide; at 90 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.201000924

upstream raw materials:

L-N-Boc-Ala

C₁₁H₁₃IN₂O₅

Downstream raw materials:

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(4-methoxy-3-nitrophenyl)propanoate

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)-3-(4-hydroxy-3-nitrophenyl)propanoate