3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile

Base Information

Chemical Name:3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile
CAS No.:1093262-56-6
Molecular Formula:C₁₄H₈Cl₂F₂N₂O
Molecular Weight:329.133
Hs Code.:

Synonyms:3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile

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Chemical Property of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile

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Technology Process of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile

There total 6 articles about 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 557-21-1
zinc(II) cyanide

: 1093262-54-4
({3-[(5-bromo-2-chloro-3-fluorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

: 1093262-56-6
3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 0.416667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 261762-91-8
6-chloro-2-fluoro-3-methylphenol

: 1093262-56-6
3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 72 h / 130 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

3.1: sodium azide / dimethyl sulfoxide / 72 h / 25 °C

4.1: water; triphenylphosphine / tetrahydrofuran / 48 h / 25 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.42 h / 120 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; sodium azide; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 176673-72-6
5-bromo-2-chloro-1,3-difluoro-benzene

: 1093262-56-6
3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-4-chloro-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 72 h / 130 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

3.1: sodium azide / dimethyl sulfoxide / 72 h / 25 °C

4.1: water; triphenylphosphine / tetrahydrofuran / 48 h / 25 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.42 h / 120 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; sodium azide; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;