tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

Base Information

Chemical Name:tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate
CAS No.:1380920-95-5
Molecular Formula:C₂₆H₃₀Cl₂F₃N₅O₂
Molecular Weight:572.458
Hs Code.:

Synonyms:tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

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Chemical Property of tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

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Technology Process of tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

There total 9 articles about tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1242268-43-4
tert-butyl 4-chloro-3-isothiocyanatobenzylcarbamate

: 1380920-94-4
5-chloro-2-methylamino-4-(3-(trifluoromethyl)piperidin-1-yl)aniline

: 1380920-95-5
tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1380920-95-5
tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dmap / dichloromethane / 18.5 h / 0 - 20 °C

2: ammonium chloride; iron / ethanol; water / 20 - 90 °C

3: dichloromethane / 4 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C

With iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 2339-78-8
1,2-dichloro-4-fluoro-5-nitrobenzene

: 1380920-95-5
tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; toluene

2.1: potassium carbonate / N,N-dimethyl-formamide / 70 - 80 °C

2.2: 26 h / 20 - 100 °C

3.1: hydrogen / platinum on activated charcoal / tetrahydrofuran; methanol / 4 h / 35 °C / 2400.24 Torr

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C

With hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;