(4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Base Information

Chemical Name:(4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol
CAS No.:543697-35-4
Molecular Formula:C₃₇H₃₇NO₉S
Molecular Weight:671.768
Hs Code.:

Synonyms:(4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

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Chemical Property of (4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

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Technology Process of (4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

There total 4 articles about (4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 622368-20-1
(4aS,6S,8R,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-one

: 543697-35-4
(4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 ℃; for 0.333333h;
DOI:10.1021/jm0205088

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 543697-35-4
(4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / camphorosulfonic acid / CHCl₃ / 1 h / Heating

2: 76 percent / DMSO; acetic anhydride / 72 h / 20 °C

3: 88 percent / L-selectride / tetrahydrofuran / 0.33 h / -78 °C

With camphor-10-sulfonic acid; acetic anhydride; L-Selectride; dimethyl sulfoxide; In tetrahydrofuran; chloroform;
DOI:10.1021/jm0205088

Reference yield:

: (2S,3S,4R,5S,6S)-2-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-4-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-3,5-diol

: 543697-35-4
(4aS,6S,7R,8S,8aS)-6-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethoxy]-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / camphorosulfonic acid / CHCl₃ / 1 h / Heating

2: 76 percent / DMSO; acetic anhydride / 72 h / 20 °C

3: 88 percent / L-selectride / tetrahydrofuran / 0.33 h / -78 °C

With camphor-10-sulfonic acid; acetic anhydride; L-Selectride; dimethyl sulfoxide; In tetrahydrofuran; chloroform;
DOI:10.1021/jm0205088