5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde

Base Information

• Chemical Name: 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde
• CAS No.: 870193-36-5
• Molecular Formula: C₂₆H₂₅ClN₂O₄
• Molecular Weight: 464.948
• Mol file: 870193-36-5.mol

Synonyms:5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde

Chemical Property of 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde

There total 3 articles about 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

t-butyl 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carboxylate (870193-35-4) → 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde (870193-36-5)

Guidance literature:

t-butyl 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carboxylate; With trifluoroacetic acid; at 20 ℃; for 0.5h;

With orthoformic acid triethyl ester; at 20 ℃; for 0.75h;

DOI:10.1016/j.tet.2005.08.075

Reference yield:

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole (151290-21-0) → 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde (870193-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphorus oxychloride / 0 °C

1.2: 84 percent / sodium hydroxide / H₂O; dimethylformamide

2.1: 43 percent / K₁₀ clay / CH₂Cl₂

3.1: trifluoroacetic acid / 0.5 h / 20 °C

3.2: 71 percent / triethylorthoformate / 0.75 h / 20 °C

With K₁₀ clay; trifluoroacetic acid; trichlorophosphate; In dichloromethane; 1.1: Vilsmeier formylation;

DOI:10.1016/j.tet.2005.08.075

Reference yield:

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole-7-carbaldehyde (362590-16-7) → 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carbaldehyde (870193-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 43 percent / K₁₀ clay / CH₂Cl₂

2.1: trifluoroacetic acid / 0.5 h / 20 °C

2.2: 71 percent / triethylorthoformate / 0.75 h / 20 °C

With K₁₀ clay; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2005.08.075

upstream raw materials:

t-butyl 5-(3-(4-chlorophenyl)-7-formyl-4,6-dimethoxyindol-2-ylmethyl)-4-ethyl-3-methylpyrrole-2-carboxylate

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole-7-carbaldehyde