ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

Base Information

Chemical Name:ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate
CAS No.:439944-59-9
Molecular Formula:C₂₈H₃₅NO₅
Molecular Weight:465.59
Hs Code.:

Synonyms:ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

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Chemical Property of ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

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Technology Process of ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

There total 2 articles about ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 36265-55-1
1,1-diphenyl-4-bromobutane

: 167414-69-9
ethyl 3-<1-(methoxycarbonyl)-4-piperidyl>-3-oxopropanoate

: 439944-59-9
ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

Guidance literature:: With sodium ethanolate; In ethanol; at 80 ℃; for 16h;
DOI:10.1021/jm020027o

Reference yield:

: 197585-43-6
1-methoxycarbonyl-4-piperidinecarboxylic acid chloride

: 439944-59-9
ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Et₃N; MgCl₂ / ethyl acetate / 20 °C

2: 61 percent / NaOEt / ethanol / 16 h / 80 °C

With sodium ethanolate; triethylamine; magnesium chloride; In ethanol; ethyl acetate;
DOI:10.1021/jm020027o

Reference yield: 24.0%

: 439944-59-9
ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

: 439944-70-4
4-(4,4-diphenylbutyl)-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol

Guidance literature:: ethyl 2-(4,4-diphenylbutyl)-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate; With sodium hydroxide; hydroxylamine hydrochloride; In methanol; at -30 ℃; for 2h;

With hydrogenchloride; In methanol; at 80 ℃; for 2h; Further stages.;
DOI:10.1021/jm020027o