(1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate

Base Information

Chemical Name:(1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate
CAS No.:1451218-42-0
Molecular Formula:C₃₀H₃₄ClNO₂
Molecular Weight:476.058
Hs Code.:

Synonyms:(1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate

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Technology Process of (1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate

There total 2 articles about (1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 95-51-2
o-chloroaniline

: 161634-63-5
(-)-(1R,3R,4S)-8-phenylmenthyl 2-diazo-2-phenylacetate

: 1451218-42-0
(1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate

Guidance literature:: With palladium dichloride; In 1,2-dichloro-ethane; at 20 - 40 ℃; for 9h; Solvent; diastereoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1039/c3ob41331d

Reference yield:

: 156208-22-9
8-Phenylmenthyl phenylacetate

: 1451218-42-0
(1R,2S,5R)-8-phenylmenthyl (R)-2-(2-chlorophenylamino)-2-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

2: palladium dichloride / 1,2-dichloro-ethane / 9 h / 20 - 40 °C / Inert atmosphere; Schlenk technique

With 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium dichloride; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1039/c3ob41331d