2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide

Base Information

Chemical Name:2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide
CAS No.:1602487-79-5
Molecular Formula:C₂₁H₃₃N₃O₄S
Molecular Weight:423.577
Hs Code.:

Synonyms:2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide

There total 4 articles about 2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 881970-52-1
2-((N,N-dimethylsulfamoyl)amino)benzoic acid

: 366014-01-9
(1R,2R)-2-(2-aminoethyl)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptane

: 1602487-79-5
2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.ejmech.2014.03.025

Reference yield:

: 7787-20-4,126-21-6
(1R)-fenchone

: 1602487-79-5
2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -85 °C / Inert atmosphere

1.2: 1 h / -85 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 48 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.025

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1602487-79-5
2-(N,N-dimethylsulfamoylamino)-N-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; toluene / 4 h / Reflux

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 48 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2014.03.025