ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate
CAS No.:1321468-55-6
Molecular Formula:C₂₂H₂₃N₅O₃
Molecular Weight:405.456
Hs Code.:

Synonyms:ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

Suppliers and Price of ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

There total 3 articles about ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.9%

: 20173-04-0
N-methyl-N-(3-pyridylmethyl)amine

: 226954-91-2
2-(5-ethoxycarbonyl-2-phenylpyrimidine-4-ylamino)acetic acid

: 1321468-55-6
ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm200516a

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 1321468-55-6
ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 10 h / 20 °C

2: sodium tetrahydroborate / ethanol / 12 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200516a

Reference yield:

: 16273-54-4,634153-62-1
N-(3-Pyridylmethylidene)methylamine

: 1321468-55-6
ethyl 4-(2-(N-methyl,N-3-pyridylmethylamino)-2-oxoethylamino)2-phenylpyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 12 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200516a