methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

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Chemical Name:methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate
CAS No.:1150620-54-4
Molecular Formula:C₂₄H₁₆F₃N₅O₃
Molecular Weight:479.418
Hs Code.:

Synonyms:methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

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Chemical Property of methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

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Technology Process of methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

There total 11 articles about methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: 1150620-53-3
4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-pyrazol-1-yl]benzonitrile

: 1148547-24-3
methyl 6-bromo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

: 1150620-54-4
methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

Guidance literature:: With triethylamine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In water; 4-methyl-2-pentanone; at 5 - 80 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1150620-54-4
methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 7 - 8 h / 115 - 120 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / -50 - 0 °C

2.2: -50 - 20 °C

3.1: triethylamine / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; 4-methyl-2-pentanone / 5 - 80 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium carbonate; triethylamine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; 4-methyl-2-pentanone;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1150620-54-4
methyl 6-[2-(4-cyanophenyl)pyrazol-3-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / ethyl acetate / 0 - 25 °C / Inert atmosphere

2.1: ethanol / 0 - 75 °C / Reflux

3.1: sodium bromate / ruthenium(III) trichloride hydrate / acetonitrile; water / 10 - 30 °C / Inert atmosphere

4.1: sulfuric acid / 0 - 55 °C / Inert atmosphere

5.1: phosphorus(V) oxybromide / acetonitrile / 64 - 67 °C

5.2: 0 - 10 °C

6.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / 20 - 65 °C / 11251.1 Torr / Inert atmosphere

7.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 17 - 25 °C

8.1: triethylamine / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; 4-methyl-2-pentanone / 5 - 80 °C / Inert atmosphere

With sodium bromate; N-Bromosuccinimide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; triethylamine; phosphorus(V) oxybromide; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); ruthenium(III) trichloride hydrate; palladium diacetate; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; 4-methyl-2-pentanone; acetonitrile;