7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

Base Information

Chemical Name:7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one
CAS No.:203395-68-0
Molecular Formula:C₂₄H₃₂N₄O₂
Molecular Weight:408.544
Hs Code.:

Synonyms:7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

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Chemical Property of 7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

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Technology Process of 7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

There total 3 articles about 7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 129722-17-4
7-{4-[4-(2-Methyl-3-nitro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

: 203395-68-0
7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 3040 Torr;
DOI:10.1021/jm940608g

Reference yield:

: 22246-18-0
7-hydroxy-3,4-dihydro-2-(1H)-quinolinone

: 203395-68-0
7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

2: 1.) NaI, 2.) Et₃N / 1.) CH₃CN, reflux, 30 min, 2.) CH₃CN, reflux, 4 h

3: 55 percent / H₂ / 5percent Pd/C / ethanol / 3040 Torr

With hydrogen; potassium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm940608g

Reference yield:

: 129722-34-5
7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone

: 203395-68-0
7-{4-[4-(3-Amino-2-methyl-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaI, 2.) Et₃N / 1.) CH₃CN, reflux, 30 min, 2.) CH₃CN, reflux, 4 h

2: 55 percent / H₂ / 5percent Pd/C / ethanol / 3040 Torr

With hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm940608g