4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime

Base Information

Chemical Name:4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime
CAS No.:130475-95-5
Molecular Formula:C₂₂H₂₅N₅O₄S
Molecular Weight:455.538
Hs Code.:

Synonyms:4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime

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Chemical Property of 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime

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Technology Process of 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime

There total 6 articles about 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 130475-10-4
3,4,5,7,8,9-hexahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5,9-trione

: 130475-95-5
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 16h; Heating;

Reference yield:

: 39978-14-8
methyl 3-amino-4-thiophenecarboxylate hydrochloride

: 130475-95-5
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 75 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / 2 h / Heating

4: 28 percent / 50percent aq. NaOH / methanol / 2 h / Heating

5: 61 percent / P₂O₅, CH₃SO₃H (1:10 / 2 h / Ambient temperature

6: 86 percent / NH₂OH*HCl, NaOAc / ethanol / 16 h / Heating

With sodium hydroxide; methanesulfonic acid; hydroxylamine hydrochloride; trimethylaluminum; sodium acetate; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; In methanol; ethanol; dichloromethane; chloroform; toluene;

Reference yield:

: 118252-16-7
ethyl (4-methoxycarbonyl)thiophene-3-carbamate

: 130475-95-5
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7-dihydro-1-thia-4,5a-diaza-acenaphthylene-3,5,8-trione 8-oxime

Guidance literature:: Multi-step reaction with 5 steps

1: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

2: 75 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / 2 h / Heating

3: 28 percent / 50percent aq. NaOH / methanol / 2 h / Heating

4: 61 percent / P₂O₅, CH₃SO₃H (1:10 / 2 h / Ambient temperature

5: 86 percent / NH₂OH*HCl, NaOAc / ethanol / 16 h / Heating

With sodium hydroxide; methanesulfonic acid; hydroxylamine hydrochloride; trimethylaluminum; sodium acetate; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; In methanol; ethanol; chloroform; toluene;