cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine

Base Information

Chemical Name:cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine
CAS No.:710974-54-2
Molecular Formula:C₁₇H₂₂F₄N₂
Molecular Weight:330.369
Hs Code.:

Synonyms:cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine

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Chemical Property of cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine

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Technology Process of cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine

There total 2 articles about cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 4-[cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

: 710974-54-2
cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 65 ℃; for 0.5h; Acidic aqueous solution;

Reference yield:

: 710981-79-6
4-(4-fluoro-2-trifluoromethyl-benzylamino)-piperidine-l-carboxylic acid tert-butyl ester

: 710974-54-2
cyclopropylmethyl-(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: Na(AcO)3BH / tetrahydrofuran

2: TFA / CH₂Cl₂

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008