3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene

Base Information

Chemical Name:3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene
CAS No.:210093-61-1
Molecular Formula:C₁₇H₂₁BrO₃S
Molecular Weight:385.322
Hs Code.:

Synonyms:3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene

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Chemical Property of 3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene

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Technology Process of 3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene

There total 3 articles about 3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 111-77-3,95507-80-5
2-(2-methoxyethoxy)ethyl alcohol

: 210093-60-0
3-Bromo-5-(4-bromomethyl-phenyl)-2-methyl-thiophene

: 210093-61-1
3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(98)00843-0

Reference yield:

: 873-75-6
4-bromobenzenemethanol

: 210093-61-1
3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / Pd(PPh₃)4, Na₂CO₃ / tetrahydrofuran; H₂O / Heating

2: 89 percent / CBr₄, PPh₃ / acetonitrile

3: 89 percent / NaH / tetrahydrofuran / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/S0040-4039(98)00843-0

Reference yield:

: 154566-69-5
3-bromo-2-methylthiophene-5-boronic acid

: 210093-61-1
3-Bromo-5-{4-[2-(2-methoxy-ethoxy)-ethoxymethyl]-phenyl}-2-methyl-thiophene

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / Pd(PPh₃)4, Na₂CO₃ / tetrahydrofuran; H₂O / Heating

2: 89 percent / CBr₄, PPh₃ / acetonitrile

3: 89 percent / NaH / tetrahydrofuran / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/S0040-4039(98)00843-0