3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine

Base Information

• Chemical Name: 3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine
• CAS No.: 76458-40-7
• Molecular Formula: C₁₉H₁₈ClN₃O₂
• Molecular Weight: 355.824
• Mol file: 76458-40-7.mol

Synonyms:3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine

Chemical Property of 3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine

There total 1 articles about 3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

acetic anhydride (108-24-7) + 7-Chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine 4-Oxide (55098-54-9) → 3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine (76458-40-7)

Guidance literature:

at 100 ℃; for 0.333333h;

DOI:10.1002/jhet.5570170504

Reference yield: 92.0%

3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine (76458-40-7) → 7-Chloro-2-ethylamino-3-hydroxy-5-phenyl-3H-1,4-benzodiazepine (76458-46-3)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; ethanol; for 3h; Ambient temperature;

DOI:10.1002/jhet.5570170504

Reference yield:

3-Acetoxy-7-chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine (76458-40-7) → 7-Chloro-2-ethylamino-3-methylphenylamino-5-phenyl-3H-1,4-benzodiazepine (76458-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 1N aq. sodium hydroxide / dioxane; ethanol / 3 h / Ambient temperature

2: 85 percent / toluene / 4 h / Heating

With sodium hydroxide; In 1,4-dioxane; ethanol; toluene;

DOI:10.1002/jhet.5570170504

upstream raw materials:

acetic anhydride

7-Chloro-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine 4-Oxide

Downstream raw materials:

7-Chloro-2-ethylamino-3-hydroxy-5-phenyl-3H-1,4-benzodiazepine

7-Chloro-3-dimethylamino-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine

7-Chloro-3-diethylamino-2-ethylamino-5-phenyl-3H-1,4-benzodiazepine

7-Chloro-2-ethylamino-5-phenyl-3-pyrrolidinyl-3H-1,4-benzodiazepine