N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

Base Information

Chemical Name:N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)
CAS No.:352665-17-9
Molecular Formula:C₂₉H₂₆N₄O₄
Molecular Weight:494.55
Hs Code.:

Synonyms:N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

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Chemical Property of N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

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Technology Process of N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

There total 5 articles about N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 352665-14-6
N-(N-pyruvoylanthraniloyl)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

: 352665-17-9
N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

Guidance literature:: With iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja010066+

Reference yield:

: 118-48-9
isatoic anhydride

: 352665-17-9
N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

Guidance literature:: Multi-step reaction with 4 steps

1: 9.8 g / benzene / 5 h / Heating

2: 82 percent / aq. NaHCO₃ / CH₂Cl₂; H₂O / 0.5 h

3: 100 percent / pyridine / methanol / 2 h / 50 °C

4: 90 percent / Ph₃P; I₂; Hunig's base / CH₂Cl₂ / 2 h / 20 °C

With pyridine; iodine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; water; benzene;
DOI:10.1021/ja010066+

Reference yield:

: 85612-29-9
N_b-(2-aminobenzoyl)-L-tryptophan methyl ester

: 352665-17-9
N-(2-acetyl-4H-3,1-benzoxazin-4-ylidene)-L-tryptophan, methyl ester, 2-(E)-(O-benzyloxime)

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / aq. NaHCO₃ / CH₂Cl₂; H₂O / 0.5 h

2: 100 percent / pyridine / methanol / 2 h / 50 °C

3: 90 percent / Ph₃P; I₂; Hunig's base / CH₂Cl₂ / 2 h / 20 °C

With pyridine; iodine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; water;
DOI:10.1021/ja010066+