3-(TRIFLUOROMETHOXY)CINNAMIC ACID

Base Information

• Chemical Name: 3-(TRIFLUOROMETHOXY)CINNAMIC ACID
• CAS No.: 175675-63-5
• Molecular Formula: C10H7 F3 O3
• Molecular Weight: 232.159
• Mol file: 175675-63-5.mol

Synonyms:2-Propenoicacid, 3-[3-(trifluoromethoxy)phenyl]-, (E)-;(E)-3-(3-Trifluoromethoxyphenyl)-2-propenoic acid

Chemical Property of 3-(TRIFLUOROMETHOXY)CINNAMIC ACID

Chemical Property:

• Melting Point: 92-96 °C(lit.)
• Boiling Point: 286℃
• Flash Point: 127℃
• PSA: 46.53000
• Density: 1.403
• LogP: 2.68300

Purity/Quality:

98%,99%, ^*data from raw suppliers

(E)-3-(3-(Trifluoromethoxy)phenyl)acrylicacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-36-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(TRIFLUOROMETHOXY)CINNAMIC ACID

There total 2 articles about 3-(TRIFLUOROMETHOXY)CINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

malonic acid (141-82-2) + 3-(trifluoromethoxy)benzaldehyde (52771-21-8,50823-91-1) → (E)-3-(trifluoromethoxy)cinnamic acid (175675-63-5)

Guidance literature:

With pyridine; piperidine; for 3h; Heating / reflux;

Reference yield:

malonic acid (141-82-2) + (E)-3-(3-Trifluoromethoxy-phenyl)-propenal → (E)-3-(trifluoromethoxy)cinnamic acid (175675-63-5)

Guidance literature:

With piperidine; pyridine;

DOI:10.1002/cbdv.202100809

Reference yield: 83.0%

methyl 6-aminocaproate hydrochloride (1926-80-3) + (E)-3-(trifluoromethoxy)cinnamic acid (175675-63-5) → 6-[3-(3-Trifluoromethoxy-phenyl)-acryloylamino]-hexanoic acid methyl ester

Guidance literature:

upstream raw materials:

malonic acid

3-(trifluoromethoxy)benzaldehyde

Downstream raw materials:

3-(3-trifluoromethoxyphenyl)acryloyl chloride

3-(3-(trifluoromethoxy)phenyl)propanoic acid

(E)-N-(2-methoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(3-(trifluoromethoxy)phenyl)acrylamide

1-(3-trifluoromethoxy-phenyl)ethanone

Refernces

• 1、 Gong, Pei-Xue,Xu, Fangning,Cheng, Lu,Gong, Xu,Zhang, Jie,Gu, Wei-Jin,Han, Wei. "Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation". supporting information. p. 5905 - 5908. Retrieved 2021/06/18.