t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate

Base Information

Chemical Name:t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate
CAS No.:551964-58-0
Molecular Formula:C₂₆H₄₂N₄O₇
Molecular Weight:522.642
Hs Code.:

Synonyms:t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate

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Technology Process of t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate

There total 6 articles about t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 144036-71-5
tert-butyl 2-(1-methylhydrazinyl)acetate

: 551964-57-9
(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionic acid

: 551964-58-0
t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2004.04.036

Reference yield: 24.0%

: 34670-47-8
1-methylhydrazinoacetic acid

: 551964-57-9
(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionic acid

: 551964-58-0
t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate

Guidance literature:: In ethyl acetate;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 551964-58-0
t-Butyl {N'-[(3R/S)-t-butoxycarbonylamino-3-(4-t-butoxycarbonylaminophenyl)propionyl]-N-methylhydrazino}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 5 percent / aq. Na₂CO₃ / 20 °C

2: 60 percent / HATU; DIEA / dimethylformamide / 12 h / 0 - 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.04.036