D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

Base Information

Chemical Name:D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu
CAS No.:225780-70-1
Molecular Formula:C₃₉H₄₂N₂O₅
Molecular Weight:618.773
Hs Code.:

Synonyms:D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

Suppliers and Price of D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

There total 1 articles about D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 13404-22-3
tert-butyl L-alaninate hydrochloride

: 184353-93-3
(2R,3S)-2-[Benzyl-(9-phenyl-9H-fluoren-9-yl)-amino]-3-methyl-succinic acid 1-methyl ester

: 225780-70-1
D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; 1.) 0 deg C, 3 h, 2.) room temperature, 12 h;
DOI:10.1016/S0968-0896(98)00254-5

Reference yield:

: 225780-70-1
D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

: (5R,8S,11R,12S,15S,18S,19S,22R)-1-Cyclohexyl-8-isobutyl-18-((1E,3E)-(5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-hepta-1,3-dienyl)-5,12,15,19-tetramethyl-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaaza-cyclopentacosane-11,22-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂, TFA, 2.) HATU, collidine / 1.) 10 percent Pd/C / 1.) MeOH, 1 atm, 13 h, 2.) 0 deg C, 2 h; room temperature, 16 h

2: 1.) HOAt, DCC, 2.) TFA, 3.) collidine / 1.) DMF, CH₂Cl₂, 0 deg C, 2 h; room temperature, 7 h, 2.) 1.5 h, 3.) DMF, 0 deg C, 2 h; room temperature, 12 h

3: 1.) pentafluorophenol, DCC, 2.) TFA, 3.) phosphate buffer / 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min

4: 44 percent / 1M LiOH / tetrahydrofuran; H₂O / 0.67 h / 0 °C

With 2,3,5-trimethyl-pyridine; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; phosphate buffer; 2,3,4,5,6-pentafluorophenol; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1016/S0968-0896(98)00254-5

Reference yield:

: 225780-70-1
D-erythro-N-(9-phenylfluoren-9-yl)-N-benzyl-β-Me-iso-Asp(OMe)-L-Ala-OtBu

: (5R,8S,11R,12S,15S,18S,19S,22R)-8-Cyclohexylmethyl-18-((1E,3E)-(5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-hepta-1,3-dienyl)-1,5,12,15,19-pentamethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaaza-cyclopentacosane-11,22-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂, TFA, 2.) HATU, collidine / 1.) 10 percent Pd/C / 1.) MeOH, 1 atm, 13 h, 2.) 0 deg C, 2 h; room temperature, 16 h

2: 1.) HOAt, DCC, 2.) TFA, 3.) collidine / 1.) DMF, CH₂Cl₂, 0 deg C, 2 h; room temperature, 7 h, 2.) 1.5 h, 3.) DMF, 0 deg C, 2 h; room temperature, 12 h

3: 1.) pentafluorophenol, DCC, 2.) TFA, 3.) phosphate buffer / 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min

4: 41 percent / 1M LiOH / tetrahydrofuran; H₂O / 1 h / 0 °C

With 2,3,5-trimethyl-pyridine; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; phosphate buffer; 2,3,4,5,6-pentafluorophenol; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1016/S0968-0896(98)00254-5