Technology Process of 12α,17β-dihydroxyandrosta-1,4-dien-3-one
There total 1 articles about 12α,17β-dihydroxyandrosta-1,4-dien-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
manganese(II) sulfate; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; iron(II) sulfate; potassium nitrate; zinc(II) sulfate;
Pseudomonas sp. NCIB 10590;
In
water;
at 28 ℃;
for 1008h;
Further byproducts given;
90percent H2, 10percent CO2, pH 7.2, anaerobically;
DOI:10.1016/S0040-4020(01)91191-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 83 percent / N,N-dimethylformamide / 48 h / 40 °C
2: 83 percent / pyridinium chlorochromate / CH2Cl2 / 24 h / Ambient temperature
3: 54 percent / pyridinium p-toluenesulfonate / benzene / 120 h / Heating
4: 21 percent / biphenyl, diphenylmethane, Li / tetrahydrofuran / 0.08 h / Heating
5: 63 percent / potassium carbonate, potassium iodide / acetone / 15 h / Heating
6: 94 percent / 4M H2SO4 / acetone / 20 h / Ambient temperature
With
biphenyl; Diphenylmethane; sulfuric acid; pyridinium p-toluenesulfonate; lithium; potassium carbonate; N,N-dimethyl-formamide; pyridinium chlorochromate; potassium iodide;
In
tetrahydrofuran; dichloromethane; acetone; benzene;
DOI:10.1071/C97147
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / N,N-dimethylformamide / 48 h / 40 °C
2: 83 percent / pyridinium chlorochromate / CH2Cl2 / 24 h / Ambient temperature
3: 54 percent / pyridinium p-toluenesulfonate / benzene / 120 h / Heating
4: 21 percent / biphenyl, diphenylmethane, Li / tetrahydrofuran / 0.08 h / Heating
5: 63 percent / potassium carbonate, potassium iodide / acetone / 15 h / Heating
With
biphenyl; Diphenylmethane; pyridinium p-toluenesulfonate; lithium; potassium carbonate; N,N-dimethyl-formamide; pyridinium chlorochromate; potassium iodide;
In
tetrahydrofuran; dichloromethane; acetone; benzene;
DOI:10.1071/C97147
