(S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

Base Information

Chemical Name:(S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate
CAS No.:1333325-46-4
Molecular Formula:C₃₃H₃₉NO₆Si
Molecular Weight:573.761
Hs Code.:

Synonyms:(S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

Suppliers and Price of (S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

There total 15 articles about (S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1333325-55-5
(S)-2-(2-hydroxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1333325-46-4
(S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol202265g

Reference yield:

: 1333325-54-4
(S)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)-2-(2-oxoethyl)but-1-yl acetate

: 1333325-46-4
(S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2: 1H-imidazole; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol202265g

Reference yield:

: 1333325-44-2
(R,E)-4-oxo-4-(2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-2-en-1-yl acetate

: 1333325-46-4
(S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium tetrachloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.1: 1H-imidazole; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; dimethylsulfide borane complex; titanium tetrachloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol202265g